Scientific Program

Saturday, September 26, 2015
Session 1
Introduction to Genetics
Chairpersons: Simon Fishel, UK, Yuval Yaron, Israel
08:30-08:35 Welcome
Simon Fishel, UK
08:35-09:05 Basic principles for the non-geneticist
Brigitte Faas, The Netherlands
09:05-09:35 Next generation sequencing: Strategies for genetic testing
Mark Hughes, USA
09:35-10:05 Technical aspects of reproductive genetics (Methods of PGS, PGD, Prenatal)
Darren Griffin, UK
10:05-10:30 Carrier screening of recessive disease: Universal screening
Gabriel Lazarin, USA
10:30-11:00 Coffee Break & Poster Viewing
Session 2
PGD and PGS: State-of-the-Art
Chairpersons: Tony Gordon, UK, Dagan Wells, UK
11:00-11:30 Development and current best practice for translocations
Francesco Fiorentino, Italy
11:30-12:00 Single gene diagnosis and aneuploidy detection using karyomapping
Tony Gordon, UK
12:00-12:30 Clinically evaluating NGS and its extra information
Dagan Wells, UK
Genetics of primary ovarian failure
Micheline Misrahi, France
13:00-14:00 Lunch Break
Session 3
The clinical value of Preimplantation Genetic Screening (PGS)
Chairpersons: Ariel Hourvitz , Israel , Zeev Shoham, Israel, Ariel Weissman, Israel
14:00-14:30 Management of PGS treatment embryo: Timing, technology, success and cost effectiveness
Richard Scott, USA
Aneuploidy in embryos: variability between centers, between patients and between cycles of the same patients
Santiago Munné, USA
Debate: Is it now unethical not to screen out an aneuploidy embryo in IVF?
For: Andreas Schmutzler, Germany
Against: Sjoerd Repping, The Netherlands
16:00-16:30 Industrial Sponsored Lecture
16:30-17:00 Coffee Break & Poster Viewing  
Session 4
Prediction of Gamete quality and viability
Chairpersons: Alan Handyside, UK, Santiago Munné, USA
17:00-17:30 Cumulus cell genomics and its predictive value
Samir Hamamah, France
17:30-18:00 Blastocoel analysis for PGS and the potential clinical value of mitochondrial screening assays
Luca Gianaroli, Italy
18:00-18:30 Ultra-sensitive mass spectrometry to look at the proteomic content of the blastocoel fluid with a view to embryo viability assessment
Maurizio Poli, UK
18:30-19:00 Update on polar body testing for detection of female meiotic errors
Alan Handyside, UK

Sunday, September 27, 2015
Session 5
Non-Invasive Prenatal Testing (NIPT): Current state of the ART
Chairpersons: Dick Oepkes, The Netherlands, Lee Shulman, USA
08:30-09:00 Introduction of NIPT in clinical practice
Dick Oepkes, The Netherlands
09:00-09:30 NIPT/MPSS: Expanding the boundaries of prenatal screening
Lee Shulman, USA
Debate : How should NIPT be used
Moderator: Dick Oepkes, The Netherlands

As primary screening to all patients
Tom Musci, USA

As contingent screening in very high and intermediate risk patients
Howard Cuckle, USA/Israel
10:30-11:00 Coffee Break & Poster Viewing
Session 6
Non-Invasive Prenatal Testing (NIPT): Future Perspectives
Chairpersons: Vincenzo Cirigliano, Spain, Yuval Yaron, Israel
Debate: NIPT for microdeletion syndromes
Pros: Amy Sehnert, USA
Cons: Tom Musci, USA
12:00-12:30 NIPD for Single-Gene Disorders
Lyn Chitty, UK
12:30-13:00 Will the Fetal Exome Contribute to the Counseling and Management of the Dysmorphic or Malformed Fetus?
Lyn Chitty, UK
13:00-14:00 Lunch Break
Session 7
Chromosomal microarrays (CMA) in Prenatal Diagnosis
Chairpersons: Brigitte Faas, The Netherlands, Mark Hughes, USA
14:00-14:30 Chromosomal microarrays - How does it work?
Vincenzo Cirigliano, Spain
14:30-15:00 Can CMA replace standard karyotyping?
Francesco Fiorentino, Italy
15:00-15:30 Counseling for Variants of Unclear Clinical Significance
Brigitte Faas, The Netherlands
Merging a comprehensive preconception carrier screening panel and chromosomal microarray analysis
Doron Behar, Israel
16:00-16:30 Coffee Break & Poster Viewing
Session 8
Genetics in infertility
Chairpersons: Simon Fishel, UK, Samir Hamamah, France, Yuval Yaron, Israel
16:30-17:00 Characterization of the molecular etiology of severe cases of infertility - a must to bring personalized medicine to the field of reproduction
Pierre Ray, France
Genetics and Infertility: Initial Analysis of a Large-Scale, Multivariate Genomics Study
Sara Bristow, USA
17:30-18:00 Gene therapy in reproductive medicine
Gregory Christman, USA
18:00-18:30 Social and legal aspects
Francoise Shenfield, UK
18:30-18:35 Closing remarks
Yuval Yaron, Israel