Scientific Program

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Thursday, April 7, 2016
Registration Desk hours: 08:00 – 19:00
09:00-12:40
SARM CONSORTIUM: ENDOMETRIAL AND EMBRYONIC GENOMICS, SEARCHING FOR BIOMARKERS IN ASSISTED REPRODUCTION
(Not for CME)
Chair: David Blesa, Spain
09:00-09:20 Introduction
David Blesa, Spain
09:20-09:40
Haplarithmisis to study haplotype architectures genome wide to single-cell resolution, enabling a generic method for preimplantation genectic diagnosis in the clinic and novel fundamental genome research.
Masoud Zamani-Esteki, Belgium
09:40-10:00 Genome-wide haplotyping of preimplantation embryos in the clinic: principles guiding embryo selection in Leuven
Eftychia Dimitriadou, Belgium
10:00-10:20
Chromosomal instability in preimplantation embryos: lessons from a cow.
Olga Tšuiko, Estonia
10:20-10:40 Coffee Break
10:40-11:10 ENPP3- A Novel biomarker for progesterone regulated Endometrial Receptivity
Lalit Kumar, Sweden
11:10-11:40 Single-cell transcriptome analysis of endometrial tissue.
Kaarel Krjutškov, Sweden
11:40-12:10 Meta-analysis of endometrial receptivity-associated genes.
Signe Altmäe, Estonia
12:10-12:40 The embryo is the cradle of chromosomal disorders, chimaerism and mixoploidy.
Joris Vermeesch, Belgium
 
WORKSHOPS
15:00-18:30
1. VIDEO LAPSE IMAGING
Capsule: The aim of the workshop is to introduce the principles of embryo development and selection and time-lapse as an embryology tool; clinical data will be provided to support its potential utility. The Clinical Embryology Units in IVI have been the first laboratories that have applied Embryoscope Time-lapse based technology for clinical use, their vast experience will be presented, together with a detailed description of the technical characteristics of by Vitrolife. We will go throughout the application of Eeva and learn from the group with the largest clinical experience, IVF Spain. Finally we will count with Merck that will present the technical features of EEVA system and will introduce a new time-lapse benchtop incubator, the Geri.
Subjects discussed will include also the long-future view of the technology, are we moving towards a 100% time-lapse laboratory?
 15:00-15:05 Introduction of the Workshop
Marcos Meseguer, Spain
 15:05-15:30
The future of the Embryology Lab; towards a 100% Time-lapse Laboatory?
Marcos Meseguer, Spain
 15:30-16:00 Embryoscope and Primovision; Pioneers on time-lapse
Francesca Ann Bahr, Denmark
 16:00-16:30 Embryokinetics: what have we learned in the last 5 years with the Embryoscope
Natalia Basile, Spain
16:30-17:00 Coffee Break
 17:00-17:45 Eeva and Geri- The synergy of two approaches of time-lapse technology
Diego Ezcurra, USA
 17:45-18:30 Clinical Experience with Eeva
Eugenia Rocafort, Spain
in parallel
14:30-18:30
in parallel
15:00-18:30
in parallel
15:00-18:30
4. ENDOMETRIAL RECEPTIVITY ARRAY
Capsule: The endometrium is a hormonally regulated organ that is non-adhesive to embryos throughout most of the menstrual cycle in humans. Endometrial receptivity refers to a hormone-limited period in which the endometrial tissue acquires a functional and transient ovarian steroid-dependent status allowing blastocyst adhesion. Personalized medicine is a well-accepted concept in reproductive medicine except for the endometrial factor that is still neglected. Our group has developed the endometrial receptivity array (ERA), a customized array of 238 genes coupled to a computational predictor capable of diagnosing a functionally receptive endometrium regardless of its histological appearance . The accuracy of the diagnostic tool ERA has been demonstrated to be superior to endometrial histology and results are completely reproducible 29 to 40 months later.
The aim of this workshop presentation is to demonstrate the diagnostic and therapeutic efficiency of the ERA in patients with implantation failure (IF), through personalization of embryo transfer (pET) and review its clinical impact in Endometriosis, Obesity as well as its relationship with endometrial thickness and pattern. We will also review the logistics about how it must be done and the next diagnostic generation test of endometrial receptivity
 15:00-15:05 Introduction
Carlos Simón, Spain
 15:05-15:45 Diagnosis of Endometrial Receptivity using ERA. Clinical Application
Carlos Simón, Spain
 15:45-16:30 Logistics of ERA. When, how and to whom
María Ruiz-Alonso, Spain
16:30-17:00
Coffee Break
 17:00-17:45 Clinical Impact of Endometriosis, Obesity and endometrial thickness and pattern in Endometrial Receptivity
Diana Valbuena, Spain
 17:45-18:30 The next diagnostic generation. ERA non invasive.
Felip Vilella Mitjana, Spain
Welcome Reception 18:30
(at the Sorrolla Palace Hotel)

Friday, April 8, 2016
 
 OVARIAN RESERVE, OOCYTES, SPERM AND EMBRYOS
08:00-10:20 Session 1: THE OVARIAN RESERVE AND OOCYTES
Chair: Carlos Simón, Spain
08:00-08:15
Introduction and Orientation
08:15-09:00
Keynote Lecture
Biomarkers. From Experimental Design to Clinical Translation: Why is it so difficult?
Kurt Barnhart, USA
09:00-9:40
Predictive Biomarkers of Ovarian Response
Carlo Alviggi, Italy
09:40-10:20
Ovarian Biomarkers to Modify the Clinical Strategy
Ernesto Bosch, Spain
10:20-10:40 Coffee Break
10:40-15:20
 Session 2: EMBRYO DIAGNOSTICS
Chair: David Gardner, Australia
10:40- 11:20
Time Lapse Imaging vs Conventional Morphology to assess Embryo Viability
Marcos Meseguer, Spain
11:20 -12:00
Use of Next Generation Sequencing (NGS) for Embryo and Blastocyst Assessment. Indications and Clinical Results
Carmen Rubio, Spain
12:00-12:40
Non-invasive Profiling of Embryos
David Gardner, Australia
12:40-14:00
Lunch
14:00-14:40
Is there any Evidence that the use of Biomarkers will Improve our Practice?
Siladitya Bhattacharya, UK
14:40-15:20
Critical Assessment of Established but Ineffective Biomarkers
Nick Macklon, UK
15:20-15:40 Coffee Break
15:40-17:40
 Session 3: THE SPERM
Chair: Denny Sakkas, USA
15:40-16:20
Translational Research: From Sperm Proteomics to the Clinic
John Aitken, Australia
16:20-17:00
DNA Fragmentation Techniques: 25 Years on what has Changed? Critical Assessment
Nicola Garrido, Spain
17:00-17:40
Novel Technologies for Selecting the Best Sperm for IVF and ICSI.
Denny Sakkas, USA

Saturday, April 9, 2016
 
 ENDOMETRIUM AND PREGNANCY
08:30-10:30
 Session 4: THE ENDOMETRIUM IN HEALTH AND DISEASE
Chair: Hilary Critchley, UK
08:30-09:10
Identifying and Personalizing the Window of Implantation. ERA Clinical Results
Carlos Simón , Spain
09:10-09:50
Endometrial Biomarkers for Endometriosis
Linda Giudice, USA
9:50-10:30
Endometrial Biomarkers for Abnormal Uterine Bleeding
Hilary Critchley, UK
10:30-11:00 Coffee Break
11:00-13:00
 Session 5: BIOMARKERS FOR NORMAL AND PATHOLOGICAL PREGNANCY
Chair: Carlos Simón, Spain
11:00-11:40
Carrier Screening Preparing for Pregnancy
Julio Martin, Spain
11:40-12:20
Biomarkers for Late Pregnancy Complications
Tamara Garrido Gómez, Spain
12:20-13:00
Barriers to implement biomarkers in clinical practice. The PGS case
David Jimenez, Spain
13:00-14:00 Lunch
14:00-17:00
Session 6: CLINICAL TRANSLATION: THE TRANSLATORS. WHICH BIOTECH COMPANIES ARE ON THE HORIZON TO HELP US
Chair: Denny Sakkas, USA
14:00-17:00 Industry Presentations
17:00-17:45 Session 7: ABSTRACT PRESENTATIONS
Chair: Denny Sakkas, USA
17:00-17:15 MiRNA Alteration Dependent On Art Outcome In Plasma Of Women At The Time Of Embryo Transfer And Pregnancy Test
Alexander Freis, Germany
17:15-17:30
The menstrual phase independent proteome of the endometrium of women with endometriosis is distinctly different from women without- results from quantitative proteomic analysis
Ying Cheong, UK
17:30-17:45
Conclusions
Hilary Critchley, UK, David Gardner, Australia, Denny Sakkas, USA,
Carlos Simón, Spain