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Thursday, June 24, 2010
Registration: 16:00
Welcome Reception: 19:00
Friday, June 25, 2010
Longevity determined by aging or by age associated disease
Capsule - The older persons population has increased and is the highest consumer of medical services. Is this determined by the biological process of aging, or by the burden of age related health problems i.e. Alzheimer’s, cardiac disease or pulmonary disease?
Chairmen: Y. Berner, Israel, B. Vellas, France
Opening remarks: B. Vellas, France, E. Topinkova, Czech Republic
DEBATE: Is aging just a collection of diseases or an intrinsic biological process?
Burden of diseases in the older persons in Europe
J.B. Baeyens, Belgium
Aging is a biological process with clinical implications
D. Ingram, USA
Is it possible to repair molecular and cellular damage of aging and to postpone age-related ill-health?
A. de Grey, UK
Treatment of dementia. When to start?
Capsule - Alzheimer's disease is a common clinical phenomenon. With certain clinical and imaging exams, we can treat it in its early stages. Innovations in therapy, mainly in slowing the progression rate of the disease, are growing. There is a question of starting this medication and innovations in therapeutic trial in healthy subjects or starting once the subjects begin to lose their cognitive abilities.
Chairmen: T. Salva, Spain, B. Vellas, France
DEBATE: Do we need to propose a therapeutic trial to Alzheimer patients with new innovative drugs?
B. Vellas, France
S. Andrieu, France
Genetic tests for Alzheimer´s disease in healthy subjects
J. Oliveira, Brazil
Oxidation and aging
Capsule - Over the last 50 years oxidative stress is one of the leading theories for the development of age associate diseases and of the aging process itself.
Longevity, inflammation and ageing
C. Franceschi, Italy
DEBATE: Aging oxidation and anti-oxidation in aging process
Oxidation is a major reason for diseases and the aging process. Can reactive oxygen species (ROS) compete or cooperate with prooxidative /antioxidative genes in aging?
I. Afanas'ev, Portugal
What are the effects of botanical compounds and direct antioxidants on oxidative stress levels and aging processes
S. Anton, USA
Limits of treatment for high blood pressure in older persons
Capsule - Vascular disease and high blood pressure are some of the main reasons for disease and disability in older persons. There is prolonged experience of decreasing vascular morbidity with the treatment of high blood pressure. Recent guidelines are very strict and raise the question of whether we have to follow them with the physiological changes in older persons and other morbidity in older persons.
Chairmen: J.M. Ribera-Casado, Spain
DEBATE: Vascular and blood pressure age related changes: Determinants, consequences and treatment.
Pro: Systolic blood pressure 110mmHg at any age
F. Mattace-Raso, The Netherlands
Con: Older person systolic blood pressure over 130 mmHg
D. Dicker, Israel
Surgery in older persons
Debate: Do pre-operative interventions reduce postoperative morbidity/mortality?
G. Gambassi,Italy
How to prepare older person patients for a surgery?
G. Silvay, USA
Debate: General anesthesia in older person patioents and Alzheimer's disease: link proven?
P.K. Mandal, India
V. Fodale, Italy
Diabetes in older persons
Capsule - Diabetes is prevalent in up to 20% of the older persons population leading to increased risk of cardiovascular, neurological and infectious diseases. How tight does the glycemic control have to be during acute disease and during stable health conditions?
DEBATE: Diabetes control in older persons and persons of very old age
Pro: Glycemic control with Hba1c of 7% in older persons
TBA
Con: The risk of tight glycemic control in older persons is not worth the benefit
D. Tessier, Canada
Saturday, June 26, 2010
New concepts in dementia
Capsule - Cognitive disorders such as Alzheimer’s disease are the most distressing conditions of aging. Some cognitive impairment can be detected early and can be treated with cognitive exercise and by drugs. Should we start the treatment as soon as the changes are detected?
Chairman: A. Korczyn, Israel
Is vascular cognitive impairment a useful concept?
A. Korczyn, Israel
DEBATE: The top 10 modifiable risk factors for dementia: Truth or fiction?
D. Gustafson, Sweden
J. Luchsinger, USA
Discussion
Treatment of overactive bladder
Capsule - Overactive bladder and urge incontinence prevalence increase in old age. Antimuscarinic drugs are the first line therapy.
DEBATE: Do we have evidence of antimuscarinics efficacy in old age? Is there a clinically significant risk of treatment?
Efficacy of antimuscarinics on OAB symptoms
E. Topinkova, Czech Republic
Anticholinergic burden and risk of antimuscarinic drugs in older persons patients and in the cognitively impaired
A. Wagg, UK
Hormone replacement therapy in the female
Capsule - Over the last 50 years significant experience has been gathered in hormone replacement therapy for woman of different ages. With great influence on the quality of life as well as certain changes in the prevalence of diseases, are the benefits worth the risks?
DEBATE: Management of menopause
Should menopause be declared as a pathological state and therefore deserve treatment?
Z. Shoham, Israel
No treatment is needed during menopause in an asymptomatic women
TBA
Estrogen does not increase beast cancer risk in a way we need to worry about
HRT and breast cancer
G. Kopernik, Israel
Does testosterone treatment improve outcome in older age?
G. Corona, Italy
Growth hormone in older persons
Chairmen: V. Khavinson, Russia
DEBATE: The use of growth hormone in older persons: Cancer risk, premature death, or life extending and anti-cancer effects?
Pro: T. Hertoghe, Belgium
Con: A. Chaturvedi, India/USA
DEBATE: The benefits and the burden of drugs in older person patients
Controversies in geriatric polypharmacy. Does drug withdrawal prolong life?
D. Garfinkel, Israel
Potential of beneficial drugs (polypill)
G. Onder, Italy
Can we treat Sarcopenia in older persons?
Capsule – Loss of muscle mass is common in older persons especially during health problems. With nutritional supplements and manipulation, can we prevent it or at least reduce its rate during active life and during acute active disease?
Moderator: C. Leeuwenburgh, USA
DEBATE: Can we treat Sarcopenia in older persons?
Pro: Sarcopenia of older persons is a reversible and treatable condition and intervention may decrease frailty in older persons
W.C. Chumlea, USA
Con: Sarcopenia of older persons is primarily an intrinsic process
J. Bauer, Germany
Summary: C. Leeuwenburgh, USA
Cerebral vascular disease in older persons
Capsule –
Chairmen: T. Grodzicki, Poland
DEBATE: Patients over 80 years of age should be given the same secondary stroke prophylaxis as those under 80
Pro: D. Russell, Norway
Con: N. Bornstein, Israel
Treatment of atrial fibrillation in older persons
Capsule – Atrial fibrillation increases with age and is responsible for many medical problems. Nevertheless, its treatment is sometimes futile and sometimes increases the risk of complications in older persons. It raises the question of whether to use anti-coagulation in order to decrease the complications from atrial fibrillation and the influence of medical treatment on the health of the patient with atrial fibrillation.
DEBATE: Atrial fibrillation in older persons?
Rate or rhythm control
Y. Berner, Israel
Anti coagluation - the benefits and the risks
A.J. Cruz Jentoft, Spain
Osteoarthritis in older persons. Can we prevent it or just treat the pain?
Capsule - Changes in the structure and metabolism of the bone is very common in older person patients in the spine, major and minor joints, leading to instability, disability and significant pain. The use of pharmacological and hormonal treatment has become the standard treatment for osteoporosis. From what treatment do older persons really benefit?
Chairman: M. Hochberg, USA
QUESTIONS:
Do treatments for symptomatic OA alter the long-term prognosis of the patient?
J. Monfort, Spain
Can OA be prevented?
G. Herrero-Beaumont, Spain
Is OA associated with reduced longevity?
M. Hochberg, USA
Strontium Ralenate reduces vertebral fractures in frail osteoporotic women. Can it be prevented?
Y. Rolland, France
Special clinical problems in the care of older persons
Capsule – Surgical wounds, pressure sores and diabetic wounds are a severe problem in older persons, which also become one of the primary financial expenses in the care of older persons. How can we use modern technology, particularly biological technology (stem cells) and growth factors to enhance regeneration and wound healing?
Chairpersons: E. Topinkova, Czech Republic
What are the ethical implications for a patient whose stem cells do not recover sufficiently for use in the proposed therapy? Does this imply an underlying defect previously undetected? Does this have lifespan implications?
N. R. Forsyth, UK
Does palliative care provision improve healthcare service efficiency and quality of life in older patients with chronic obstructive pulmonary disease?
A. M. Yohannes, UK
Sleeping disorders
Capsule – Sleeping disorders are very common in older persons. Drug side effects are very prevalent. How can we optimally manage these disorders which influence the quality of life of the patient as well as his environment?
Use of alternative medicine for sleeping disorders
W. Winit-Watjana, UK
Use of drugs
Y. Berner, Israel
Role of caloric restriction in human aging
Capsule – Since the 1930’s caloric restriction remains the main method for longevity in different species. Caloric restriction in humans may increase health risks especially malnutrition. Can we recommend caloric restriction at a younger age in order to reach longevity in better health? Should certain people gain weight and remain obese in order to survive the longest?
Chairpersons: Y. Berner, Israel, B. Vellas, France
Molecular mechanisms of lifespan extension by calorie restriction
C. Leeuwenburgh, USA
Are Sirtuins true regulators of lifespan in higher organisms, and do they influence calorie restriction?
R. De Cabo, USA
Turning anti-aging genes against cancer
V. Longo, USA
Nutritional modulation of aging and age-associated diseases by caloric restriction in humans
TBA
Nutritional mitigation of oxidative and inflammatory stress signal and brain aging
J. Joseph, USA
Discussion
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