The Scientific Program - Epilepsy

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 Thursday, April 04, 2019

Hall A-CAJAL

13:45-15:15

SESSION 3 | PLENARY LECTURES: EPILEPSY

Chairpersons:

Mar Carreno, Spain & Vladimir Donath, Slovakia

13:45-14:15

Epilepsy genetics and precision therapies – trials and tribulations: Samuel Berkovic, Australia

14:15-14:45

Gene therapy in epilepsy:  Matthew Walker, UK

14:45-15:15

How will new devices impact the diagnosis and treatment of seizures? Michael Sperling, USA

15:15-15:30

Coffee Break


Friday, April 05, 2019

Hall B-PICASSO

07:30-08:30

Chairpersons: Zaid Afawi, Israel

FREE COMMUNICATIONS, EPILEPSY & PME

Overlap of the pitt – Hopkins and Lennox-Gastaut syndromes: Biljana Dapic Ivancic, Croatia

Prevalence of headache among patients with epilepsy: Ewa CzapiƄska-Ciepiela, Poland

08:30-10:10

SESSION 9 | IMMUNE THERAPY IN EPILEPSY; NON EPILEPTIC SEIZURES: PSYCHOGENIC OR NOT?

Chairpersons:

Nandan Yardi, India & Juan José Poza, Spain

08:30-09:20

Should we routinely prescribe immune modulatory therapy to patients with refractory adult-onset epilepsy who also develop psychiatric or cognitive impairment?

Capsule: Autoimmune epilepsy is often accompanied by cognitive, behavioral, psychiatric or motor symptoms.  However, such symptoms are often present in epilepsy patients without an autoimmune cause. Diagnosis of an autoimmune disease may be challenging.Should autoimmune treatment be initiated in people without known antibodies who have accompanying symptoms?

08:30-08:40

Host: Dana Ekstein, Israel

08:40-08:55

Pro: William Theodore, USA

08:55-09:10

Con: Martin Holtkamp, Germany

09:10-09:20

Discussion and rebuttals

09:20-10:10

Are non-epileptic seizures really psychogenic?

Capsule: A variety of non-epileptic behaviors may be misdiagnosed as epileptic seizures.  Many are deemed psychogenic in nature, particularly when co-existing psychiatric morbidity is present. Is the presumption of a psychogenic cause supported by evidence?

09:20-09:30

Host: Alla Guekht, Russia

09:30-09:45

Pro: Curt W LaFrance, USA

09:45-10:00

Con: Amos Korczyn, Israel

10:00-10:10

Discussion and rebuttals

10:10-10:25

Coffee Break

10:25-12:05

SESSION 10 | EPILEPSY: TREATMENT OF RESISTANT SEIZURES

Chairpersons:

Arie Weinstock, USA & Nana Tatishvili, Georgia

10:25-11:15

Should antiepileptic drugs be pushed to high doses and levels before switching to or adding a new drug?

Capsule: Traditional practice has been to raise doses of antiepileptic medication to achieve relatively high levels before switching to or adding another agent.  Is this practice appropriate, or is failure at low dose indicative of treatment failure?

10:25-10:35

Host: Manuel Toledo, Spain

10:35-10:50

Pro: Elinor Ben-Menachem, Sweden

10:50-11:05

Con: Martin Brodie, UK

11:05-11:15

Discussion and rebuttals

11:15-12:05

Should vagus nerve stimulation (VNS) be recommended early in the course of illness when seizures fail to respond to medication and cause falling or generalize?

Capsule: VNS has the potential to moderately reduce seizure frequency.  Should early use be advised primarily for patients whose seizures may cause injury, or should VNS be more broadly applied?  What benefits would be expected in either situation – do patients with non-injurious seizures gain sufficiently to warrant treatment? 

11:15-11:25

Host: Zeljka Petelin Gadze, Croatia

11:25-11:40

Pro: Antonio Gil-Nagel, Spain

11:40-11:55

Con: Ivan Rektor, Czech Republic

11:55-12:05

Discussion and rebuttals

13:05-14:15

Lunch Break

13:15-:14:15

Meet the Expert – Epilepsy (Lafora)

Spotlight on the antiepileptic drug eslicarbazepine acetate: sharing experience from clinical practice:

Vicente Villanueva, Spain

14:15-15:45

SESSION 11 | LACTATION IN EPILEPSY; CANNABIS?

Chairpersons:

Andry Dubenko, Ukraine & Xiana Rodríguez Osorio, Spain

14:15-14:55

Should women breastfeed if they take anticonvulsant medication? 

Capsule: Breastfeeding is generally recommended as a healthy practice. However, antiepileptic drugs are delivered to babies via breast milk.  Is breastfeeding a sensible and safe practice for a baby whose mother takes an antiepileptic drug?

14:15-14:25

Host: Ilan Blatt, Israel

14:25-14:35

Yes: Martin Brodie, UK

14:35-14:45

No: Alla Guekht, Russia

14:45-14:55

Discussion and rebuttals

14:55-15:45

Should we prescribe medical marijuana for adult patients with drug-resistant epilepsy? 

Capsule: Some chemical constituents of marijuana may have anti-seizure effects, and Dravet and Lennox-Gastaut syndromes respond to cannabidiol. Do we know enough about medical marijuana to advise its use in adults with refractory epilepsy?

14:55-15:05

Host: Martin Holtkamp, Germany

15:05-15:20

Yes: Elson So, USA

15:20-15:35

No: Ilan Blatt, Israel

15:35-15:45

Discussion and rebuttals

15:45-16:00

Coffee Break

16:00-19:00

SESSION 12 | EPILEPSY: ADVANCED MRI; GENETICS

Chairpersons:

Tetyana Litovchenko Ukraine

16:00-16:50

Are genetic data likely to be of major importance in the personalized treatment of epilepsy patients?

Capsule: In addition to being causative in some rare epilepsies, genetic variants may play a role in susceptibility to more common types of epilepsy.  Can these genetic features be used to guide management in individual patients?

16:00-16:10   

Host: Michael Sperling, USA

16:10-16:25  

Likely: Samuel Berkovic, Australia

16:25-16:40

Unlikely: William Theodore, USA

16:40-16:50

Discussion and rebuttals

16:50-17:40

Should MRI scans undergo routine post-processing if visual inspection is normal in people with epilepsy?

Capsule: A variety of sophisticated computer techniques can be employed in the analysis of MRI scans.  When visual inspection fails to reveal an abnormality, do these techniques improve diagnosis, and is their use worthwhile? 

16:50-17:00

Host: Manuel Toledo, Spain

17:00-17:15

Yes: Matthias Koepp, UK

17:15-17:30

No: Elson So, USA

17:30-17:40

Discussion and rebuttals

17:40-19:00

Epilepsy Cases, Michael Sperling, USA, and Manjari Tripathi, India

Capsule: Challenging cases will be presented to participants for discussion

END OF FRIDAY HALL B- PICASSO


Saturday, April 06, 2019

Hall C- DE FALLA

07:00-08:00

E-Poster Presentations

08:00-10:40

SESSION 32 | PROGRESSIVE MYOCLONUS EPILEPSIES (PME)

Chairpersons:

Rimma Gamirova, Russia

Capsule: PME's are rare, but very challenging epilepsies to manage.  The majority of cases can now be given a specific diagnosis, and new disorders have been recently described.  Here we will discuss the diagnostic approach, insights from the new genetics, treatment with conventional anti-epileptic drugs and emerging precision therapies.

08:00-08:05

Welcome, introduction, learning objectives: Jose Serratosa, Spain

08:05-08:35

PMEs:  Clinical diagnosis, new forms and epilepsies on the borderland: Samuel Berkovic, Australia                      

08:35-09:05

Emerging treatments for the treatment of PME: Pasquale Striano, Italy

09:05-09:35

Enzyme replacement therapy for CLN2: Marina Trivisano, Italy

09:35-10:05

Lafora disease: Neurobiology and new therapeutic strategies: Jose Serratosa, Spain

10:05-10:30

Management of MERRF patients including myoclonic epilepsy: Josef Finsterer, Austria